Apoptosis Reagents and Kits
AdipoGen SB202190,Chemical. CAS: 152121-30-7
SB202190, AdipoGen Life Sciences. Chemical. CAS: 152121-30-7. Formula: C20H14FN3O. MW: 331.3. Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Autophagic vacuole inducer
Abcam Human HLA-A knockout A-431 cell lysate.
Human HLA-A knockout A-431 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Caspase-10 Rabbit pAb
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Sigma Aldrich Fine Chemicals Biosciences Mouse Tumor Necrosis facto
Tumor Necrosis factor (TNf ) is a proinflammatory cytokine. It is a transmembrane protein and the final protein is devoid of the extracellular domain. TNf -converting enzyme (TACE) catalyzes the formation of the soluble homotrimer TNf .
Revvity Health Sciences Inc Cellaca PLX, Annexin V-FITC/PI Apoptosis Kit, 100 Tests
Cellaca PLX, Annexin V-FITC/PI Apoptosis Kit, 100 Tests
Biotium Apoptosis Assays Fluorescent Proteins Nucleotides Other Conjugates Annexin V Conjugates Unlabeled 1/EA
This product is recombinant Human Annexin V expressed from E coli It is supplied lyophilized and is compatible with dye conjugation to stain phosphatidylserine on the surface of apoptotic cells Unit size 1 mg
Medchemexpress LLC Pyrimidine, 2-[4-(2-pyrazinyl)-1-piperazinyl]- | 137448-39-6 | 98.0% | 242.28 | 5 MG
HIV-1 inhibitor-47 is an inhibitor of HIV-1 that inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. This compound is also involved in the synthesis of 1-(2-pyrimidinyl)piperazine derivatives, which have potential antianxiety, antidepressant, and antipsychotic effects. It targets APOBEC3G and the HIV-1 Vif-APOBEC3G interaction.
- Inhibits HIV-1
- Inhibits vif-dependent degradation of human APOBEC3G
- Potent inhibition with an IC50 value of 14.33 μM
- Involved in 1-(2-pyrimidinyl)piperazine derivatives synthesis
- Exhibits potential antianxiety, antidepressant, and antipsychotic effects
- Targets APOBEC3G-apolipoprotein B mRNA editing enzyme catalytic subunit 3G (human)
- Modulates the HIV-1 Vif-APOBEC3G interaction
ABclonal Technology Annexin A4/Annexin IV Rabbit pAb
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene.
Cytek Biosciences Inc Caspase-3 7 Kit Amnis
Product Name: Muse Caspase-3/7 Kit
Cytek Catalog Number: MCH100108
Product Class: Guava Muse Reagent
Type: Muse
Size: 100 Tests
Sartorius Mito Membrane Potential
No wash protocol – just add and read for fast easily automated workflow.Multiplex with Qbeads PlexScreen kits for richer content.PrincipleMitochondrial membrane potential is determined by sequestration of a small fluorescent molecule inside the lumen of intact mitochondria with an active membrane potential. Upon mitochondrial depolarization the dye leaks into the cytoplasm and the cell exhibits a decrease in fluorescence.
Medchemexpress LLC Annexin A1/ANXA1 protein, human | ≥ 95% | 34-39 kDa | 100 UG
Annexin A1 protein, human, is a Ca2+-dependent phospholipid binding protein located on the cytosolic face of the plasma membrane. It plays multifunctional roles in innate and adaptive immunity, primarily regulating inflammatory cells and inflammation resolution by inhibiting neutrophil transmigration and recruitment at inflammatory sites. This protein also inhibits phospholipase A2 activity and binds 2-4 calcium ions with high affinity.
- Inhibits phospholipase A2 activity
- Binds 2-4 calcium ions with high affinity
- Regulates inflammatory cells and inflammation resolution
- Inhibits neutrophil transmigration and recruitment
Medchemexpress LLC Flavokawain C | 37308-75-1 | 20 MG
Flavokawain C is an orally active natural chalcone that inhibits the proliferation of various cancer cells through multiple mechanisms.
- Inhibits cancer cell proliferation
- Upregulates GADD153, p21, and p27
- Modulates Akt and JNK phosphorylation
- Activates caspase subtypes; induces PARP-1 cleavage
- Elevates intracellular ROS; induces apoptosis
- Activates AMPK/mTOR pathway; induces autophagy
- Inhibits glycolysis (decreases GLUT1 and HK2)
- Reduces angiogenesis (decreases Ang-1 and VEGF)
- Increases γ-H2AX levels; induces DNA damage
- Shows anti-tumor activity in mouse xenograft models
Medchemexpress LLC Margatoxin | 145808-47-5 | 99.17% | 4178.95 | 1 MG
Margatoxin, an alpha-KTx scorpion toxin, is a high-affinity inhibitor of Kv1.3 (Kd=11.7 pM). This 39 amino-acid-long peptide is isolated from the venom of the scorpion *Centruroides margaritatus* and is widely used in ion channel research.
- High affinity inhibitor of Kv1.3, Kv1.2, and Kv1.1
- Isolated from *Centruroides margaritatus* scorpion venom
- Used in ion channel research
- Decreases thioglycollate-induced leukocyte transmigration in mice
Abcam Human PVR (Poliovirus Receptor) knockout HEK-293T cell lysate.
Human PVR (Poliovirus Receptor) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement